Author contributions: V. All authors discussed the results and commented on the manuscript. Table S2. Arm-specific markers of adherence and changes in risk factors, including arm 1 after crossover to FMD, and summary of FMD arms 1 and 2. Table S4. Changes in risk factors and metabolic markers of adherence 3 months after intervention. Calorie restriction or changes in dietary composition can enhance healthy aging, but the inability of most subjects to adhere to chronic and extreme diets, as well as potentially adverse effects, limits their application. We compared subjects who followed 3 months of an unrestricted diet to subjects who consumed the FMD for 5 consecutive days per month for 3 months. Three FMD cycles reduced body weight, trunk, and total body fat; lowered blood pressure; and decreased insulin-like growth factor 1 IGF
Nature , — Although our results suggest that cycles of the plant-based FMD might be safe for elderly individuals, additional studies are necessary to determine its safety for subjects who are 70 years and older. Cancer Epidemiol. Six of the 52 subjects enrolled in the FMD arm withdrew from the study because of scheduling conflicts, five withdrew because of unspecified personal issues, and two participants were excluded from the study because of noncompliance to the FMD protocol. So I think that was the perfect meal because it has a little bit of everything. The estimated control group mean SD IGF-1 of 97 used published data on males and females aged 26 to 40 years Find articles by Hamed Mirzaei.
Valter Longo is longl Edna Fastimg. For example, fasting on a Monday and Thursday each week. The statements on this site have not been evaluated by the Medicines and Healthcare products Regulatory Agency or the Food and Drug Administration. Diet J. Statistical analyses were performed on diiet data. Calorie restriction or changes in dietary longo can enhance healthy aging, but the inability of longo subjects to adhere to mimicking and extreme diet, as well as potentially adverse effects, limits their application. The overall comparability at baseline between the fasting and both FMD arms, as well as the comparable response to the Fasting arm 2 and arm 1 after crossover suggests no major differences in response for those subjects who completed the trial. Sci 54, B—B