High-fat diets may lead to anxiety and impaired memory, says a new study. Find out if that includes the healthy fats, like the ones in your high-fat, low-carb diet. Before you start ordering bar food tonight, you should know that those french fries are doing way more than just adding some mass to your middle: Mice who were fed a high-fat diet had higher anxiety levels, impaired memory, and more markers of inflammation in both their brain and body, according to a new study in Biological Psychiatry. Try these 6 Foods to Fix Your Mood. Researchers attribute this effect to a high-fat diet changing the mix of bacteria in the gut. What does your gut have to do with your brain? There are two promising theories. The other viable explanation is that a high-fat diet compromises the integrity of the intestines. The fats create inflammation and negative bacteria, which can weaken the system’s lining. And once inflammatory markers are in your blood, they can travel to your brain and inhibit the tiny blood vessels from expanding, compromising your cognitive abilities.
Gene ontology GO enrichment analysis revealed that the hypothalamic adenylate cyclase pathway, a major contributor in the regulation of PKA signaling, were also affected by consumption of an HFD Fig. Using lipidomic and transcriptomic methods, we identified a mechanism that links exposure to a high-fat diet HFD in mice with alterations in hypothalamic function that lead to depression. Transl Psychiatry 9, Rare genetic mutations in the central melanocortin pathway are responsible for the development of monogenic obesity in humans 2. Avoiding or stopping smoking is also essential for optimal overall health. Regarding the role of fat intake, Hu et al. Although the low fat diet recommendations have been shown to be unfounded, the public health crisis triggered these faulty guidelines continues. The people on both diets lost an impressive amount of weight – about 30 pounds on average in a year. Robichaud, A. USA , —
Dietary fats can enter the brain through the bloodstream, and cause alterations that could lead to depression, according to a study that may pave the way for new therapies to treat the disorder. The team also found that by decreasing the expression of a specific enzyme called phosphodiesterase, symptoms of obesity-linked depression can be reduced. The team from University of Glasgow in the UK conducted a study in mice to show how dietary habits are linked to mental health. The study, published in the journal Translational Psychiatry, shows that saturated fatty acids enter the brain through the bloodstream, and thereafter accumulate and affect crucial brain signals related to depression. Obesity and depression have long been linked, with previous clinical studies finding an association between these two conditions. However, until now, the mechanisms of how obesity affects depression and vice versa have not been fully understood.