As a predictor of potential clinical outcome, we performed a systematic review of controlled studies that assessed experimental stroke outcome in rodents maintained on special diets calorie restriction, ketogenic diet or following the direct administration of ketone bodies. Pre-clinical studies were identified by searching web databases and the reference lists of relevant original articles and reviews. Sixteen published studies a total of experimental animals met specific criteria and were analyzed using Cochrane Review Manager software. This resulted in objective evidence to suggest beneficial effects of the ketogenic pathway on pathologic and functional outcomes following experimental stroke. Such strategies would, therefore, be predicted to benefit both cardio- and cerebro-vasculature Mattson and Wan, ; Yamada, To provide a prediction of potential clinical outcome we performed a systematic review and meta-analysis of controlled rodent studies that assessed stroke outcome where the use of ketone bodies as an energy source had been promoted. These include ketogenic diets, as well as calorie restriction, which promote the use of triacylglycerols and fatty acids. In addition, ketone bodies can be directly administered. All three dietary interventions are evaluated here.
Visit Shop. I told my husband to take me immediately to the hospital we live about minutes from it. I could not believe that I was having a stroke; and I say was having because when I was at home it started. Footnotes The authors declare that they have no conflicts of interest. No permission is required from the authors or the publishers. Share your story Do you have a success story you want to share on this blog? Talk with your doctor and family members or friends about deciding to join a study. Sorry, your blog cannot share posts by email. And it is possible. Anne N. Beneficial effect of 1,3-Butanediol on cerebral energy metabolism and edema following brain embolization in rats.
Ischemic stroke is a leading cause of death and disability in the world. Many mechanisms contribute in cell death in ischemic stroke. On the basis of these mechanisms, it is postulated that ketogenic diet could provide benefits to treatment of cerebral ischemic injuries. Nowadays, Ischemic stroke is one of the major health problems worldwide. This results in the occurrence of ischemic stroke 4 and initiation of divergent sequence of cellular dysfunctions in a limited area of brain. Indeed immediately after stroke, the central part of brain parenchyma faced to the marked blood supply decline, becomes depolarized, enlarged and eventually undergoes necrotic procedure. This necrotic tissue is surrounded by a zone of moderate injured tissue, termed as ischemic penumbra.
Abstract As a predictor of potential clinical outcome, we performed stroke systematic review of controlled studies that assessed experimental recovery outcome in rodents maintained on diet diets calorie restriction, ketogenic diet or following the direct administration of ketone bodies. If it was. I have also added IF and the once-a-day meal. I felt so bad… Everything keto me.